منابع مشابه
Programmed translational frameshifting.
Errors that alter the reading frame occur extremely rarely during translation, yet some genes have evolved sequences that efficiently induce frameshifting. These sequences, termed programmed frameshift sites, manipulate the translational apparatus to promote non-canonical decoding. Frameshifts are mechanistically diverse. Most cause a -1 shift of frames; the first such site was discovered in a ...
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BACKGROUND Telomeres are replicated in most eukaryotes by the enzyme telomerase, a specialized reverse transcriptase. A genetic screen in Saccharomyces cerevisiae designed to detect telomerase components previously led to the identification of four EST ('ever shorter telomeres') genes which are required for telomerase function in vivo. This report describes the cloning and characterization of E...
متن کاملDynamic pathways of21 translational frameshifting
Spontaneous changes in the reading frame of translation are rare (frequencyof 10 to 10 per codon), but canbe inducedby specific features in the messenger RNA (mRNA). In the presence of mRNA secondary structures, a heptanucleotide ‘slippery sequence’ usually defined by the motif X XXY YYZ, and (in some prokaryotic cases) mRNA sequences that base pair with the 39 end of the 16S ribosomal rRNA (in...
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Title of Document: mRNA SUICIDE: DESTABILIZATION BY PROGRAMMED RIBOSOMAL FRAMESHIFTING Jonathan L. Jacobs, Ph.D., 2006 Directed By: Associate Professor Jonathan D. Dinman, Department of Cell Biology & Molecular Biology Cis-acting mRNA elements that promote programmed -1 ribosomal frameshifting (-1 PRF) redirect a fraction of translating ribosomes into a new translational reading frame. In virus...
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ژورنال
عنوان ژورنال: Microbiological reviews
سال: 1996
ISSN: 0146-0749
DOI: 10.1128/mmbr.60.1.103-134.1996